Anita T. Layton

  • Robert R. & Katherine B. Penn Professor of Mathematics
  • Professor in the Department of Mathematics
  • Professor of Biomedical Engineering (Secondary)
External address: 213 Physics Bldg, Durham, NC 27708
Internal office address: Box 90320, Durham, NC 27708-0320
Phone: (919) 660-6971

Research Areas and Keywords

Biological Modeling
mathematical biology, mathematical physiology, mathematical modeling, kidney physiology, renal hemodynamics, diabetes, multiscale modeling, fluid-structure interactions, computational fluid dynamics, numerical partial differential equations, feedback control, systems biology
Computational Mathematics
mathematical biology, mathematical physiology, mathematical modeling, kidney physiology, renal hemodynamics, diabetes, multiscale modeling, fluid-structure interactions, computational fluid dynamics, numerical partial differential equations, feedback control, systems biology
PDE & Dynamical Systems
mathematical biology, mathematical physiology, mathematical modeling, kidney physiology, renal hemodynamics, diabetes, multiscale modeling, fluid-structure interactions, computational fluid dynamics, numerical partial differential equations, feedback control, systems biology

Mathematical physiology. My main research interest is the application of mathematics to biological systems, specifically, mathematical modeling of renal physiology. Current projects involve (1) the development of mathematical models of the mammalian kidney and the application of these models to investigate the mechanism by which some mammals (and birds) can produce a urine that has a much higher osmolality than that of blood plasma; (2) the study of the origin of the irregular oscillations exhibited by the tubuloglomerular feedback (TGF) system, which regulates fluid delivery into renal tubules, in hypertensive rats; (3) the investigation of the interactions of the TGF system and the urine concentrating mechanism; (4) the development of a dynamic epithelial transport model of the proximal tubule and the incorporation of that model into a TGF framework.

Multiscale numerical methods. I develop multiscale numerical methods---multi-implicit Picard integral deferred correction methods---for the integration of partial differential equations arising in physical systems with dynamics that involve two or more processes with widely-differing characteristic time scales (e.g., combustion, transport of air pollutants, etc.). These methods avoid the solution of nonlinear coupled equations, and allow processes to decoupled (like in operating-splitting methods) while generating arbitrarily high-order solutions.

Numerical methods for immersed boundary problems. I develop numerical methods to simulate fluid motion driven by forces singularly supported along a boundary immersed in an incompressible fluid.

Education & Training
  • Ph.D., University of Toronto (Canada) 2001

  • M.S., University of Toronto (Canada) 1996

  • B.A., Duke University 1994

  • B.S., Duke University 1994

Dantzler, WH, Layton, AT, Layton, HE, and Pannabecker, TL. "Urine concentrating mechanism in the inner medulla: function of the thin limbs of Henle’s loops (Accepted)." Clinical Journal of the American Society of Nephrology. (August 2012). (Academic Article)

Sgouralis, I, and Layton, AT. "Autoregulation and conduction of vasomotor responses in a mathematical model of the rat afferent arteriole." Am J Physiol Renal Physiol 303.2 (July 15, 2012): F229-F239. Full Text

Layton, AT, Moore, LC, and Layton, HE. "Signal transduction in a compliant thick ascending limb." Am J Physiol Renal Physiol 302.9 (May 1, 2012): F1188-F1202. Full Text

Savage, NS, Layton, AT, and Lew, DJ. "Mechanistic mathematical model of polarity in yeast." Mol Biol Cell 23.10 (May 2012): 1998-2013. Full Text

Layton, AT, Gilbert, RL, and Pannabecker, TL. "Isolated interstitial nodal spaces may facilitate preferential solute and fluid mixing in the rat renal inner medulla." Am J Physiol Renal Physiol 302.7 (April 1, 2012): F830-F839. Full Text

Layton, AT, Dantzler, WH, and Pannabecker, TL. "Urine concentrating mechanism: impact of vascular and tubular architecture and a proposed descending limb urea-Na+ cotransporter." Am J Physiol Renal Physiol 302.5 (March 1, 2012): F591-F605. Full Text

Layton, AT, Pham, P, and Ryu, H. "Signal transduction in a compliant short loop of Henle." Int J Numer Method Biomed Eng 28.3 (March 2012): 369-383. Full Text

Li, Y, and Layton, AT. "Accurate computation of Stokes flow driven by an open immersed interface." Journal of Computational Physics 231.15 (2012): 5195-5215. Full Text

Layton, AT. "Modeling transport and flow regulatory mechanisms of the kidney." ISRN Biomath 2012 (2012): ID: 170594, 18 pages-. (Academic Article)

Sgouralis, I, and Layton, AT. "Autoregulation and conduction of vasomotor responses in a mathematical model of the rat afferent arteriole." Am J Physiol Renal Physiol 303.F229-F239 (2012). (Academic Article)

Pages