Determining Risk Factors for Triple Whammy Acute Kidney Injury: Sex-specific Modeling and Analysis

Determining Risk Factors for Triple Whammy Acute Kidney Injury: Sex-specific Modeling and Analysis

Graduate/faculty Seminar, special SIAM-AWM Graduate Student Talk

Jessica Leete (Duke University, Mathematics)

Friday, October 25, 2019 -
3:30pm to 4:30pm
Location: 
Physics 235

Concurrent use of a diuretic, a renin-angiotensin system (RAS) inhibitor, and a nonsteroidal anti-inflammatory drug (NSAID) significantly increases the risk of acute kidney injury (AKI). This phenomenon is known as 'triple whammy'. Diuretics and RAS inhibitors, such as an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB), are often prescribed in tandem for the treatment of hypertension, whereas some NSAIDs, such as ibuprofen, are available over the counter. As such, concurrent treatment with all three drugs is not uncommon. The goals of this study are to better understand the mechanisms underlying the development of triple whammy AKI and to identify physiological factors that may increase an individual's susceptibility. To accomplish these goals, we utilize computational models of long-term blood pressure regulation. We found that individual variation in water intake or the myogenic response as well as high dosages of these drugs may predispose triple whammy patients to develop AKI. The computational models used include variables describing the heart and circulation, kidney function, sodium and water reabsorption in the nephron and the RAS, and are parameterized separately for men and women.

Last updated: 2019/11/14 - 10:31pm