- Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences
- Assistant Professor of Biomedical Engineering
- Assistant Professor of Mathematics (Secondary)
- Assistant Professor of Computer Science (Secondary)
- Member of the Duke Cancer Institute
My research in biomedical simulation and high-performance computing focuses on the development of new computational tools that we use to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.
Almendro, V, Cheng, Y-K, Randles, A, Itzkovitz, S, Marusyk, A, Ametller, E, Gonzalez-Farre, X, Muñoz, M, Russnes, HG, Helland, A, Rye, IH, Borresen-Dale, A-L, Maruyama, R, van Oudenaarden, A, Dowsett, M, Jones, RL, Reis-Filho, J, Gascon, P, Gönen, M, Michor, F, and Polyak, K. "Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity." Cell Reports 6.3 (February 2014): 514-527. Full Text
Randles, A, Draeger, E, and Michor, F. "Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations." Computing in Cardiology 41.January (January 1, 2014): 217-220.
You, Y, Fu, H, Song, SL, Randles, A, Kerbyson, D, Marquez, A, Yang, G, and Hoisie, A. "Scaling Support Vector Machines on modern HPC platforms." Journal of Parallel and Distributed Computing (2014). Full Text
Keyes, DE, McInnes, LC, Woodward, C, Gropp, W, Myra, E, Pernice, M, Bell, J, Brown, J, Clo, A, Connors, J, Constantinescu, E, Estep, D, Evans, K, Farhat, C, Hakim, A, Hammond, G, Hansen, G, Hill, J, Isaac, T, Jiao, X, Jordan, K, Kaushik, D, Kaxiras, E, Koniges, A, Lee, K, Lott, A, Lu, Q, Magerlein, J, Maxwell, R, McCourt, M, Mehl, M, Pawlowski, R, Randles, AP, Reynolds, D, Rivière, B, Rüde, U, Scheibe, T, Shadid, J, Sheehan, B, Shephard, M, Siegel, A, Smith, B, Tang, X, Wilson, C, and Wohlmuth, B. "Multiphysics simulations." The International Journal of High Performance Computing Applications 27.1 (February 2013): 4-83. Full Text
Randles, A, Baecher, M, Pfister, H, and Kaxiras, E. "A Lattice Boltzmann Simulation of Hemodynamics in a Patient-Specific Aortic Coarctation Model." Ed. O Camara, T Manso, M Pop, K Rhode, M Sermesant, and A Young. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges: Third International Workshop, STACOM 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers (2013): 17-25. Full Text
Randles, AP. "Massively parallel model of evolutionary game dynamics." Proceedings - 2012 SC Companion: High Performance Computing, Networking Storage and Analysis, SCC 2012 (December 1, 2012): 1531-. Full Text
Randles, A, Baecher, M, Pfister, H, and Kaxiras, EK. "A Lattice Boltzmann Simulation of Hemodynamics in a Patient-Speci c Aortic Coarctation Model." Ed. O Camara, M Pop, T Mansi, M Sermesant, and A Young. Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges: 7746 (October 5, 2012): 17-25. Full Text
Borkin, MA, Gajos, KZ, Peters, A, Mitsouras, D, Melchionna, S, Rybicki, FJ, Feldman, CL, and Pfister, H. "Evaluation of artery visualizations for heart disease diagnosis." IEEE transactions on visualization and computer graphics 17.12 (December 2011): 2479-2488. Full Text
Robson, B, Li, J, Dettinger, R, Peters, A, and Boyer, SK. "Drug discovery using very large numbers of patents. General strategy with extensive use of match and edit operations." Journal of Computer-Aided Molecular Design 25.5 (May 2011): 427-441. Full Text
Jiang, K, Thorsen, O, Peters, A, Smith, B, and Sosa, CP. "An Efficient Parallel Implementation of the Hidden Markov Methods for Genomic Sequence-Search on a Massively Parallel System." IEEE Transactions on Parallel and Distributed Systems 19.1 (January 2008): 15-23. Full Text
Randles, A, and Zeger, L. "Efficient Resource Allocation for Broadcasting Multi-Slot Messages With Random Access with Capture." IEEE Military Communications Conference. November 7, 2011 - November 10, 2011. Baltimore, MD. IEEE, October 2011.
Randles, A, Melchionna, S, Kaxiras, E, Latt, J, Sircar, J, Bernaschi, M, Bisson, M, and Succi, S. "Multiscale simulation of cardiovascular flows on the IBM Bluegene/P: full heart-circulation system at red-blood cell resolution." ACM/IEEE International Conference for High Performance Computing, Networking, Storage, and Analysis. November 13, 2010 - November 19, 2010. New Orleans, LA. ACM IEEE, November 2010.
Randles, A. "Parallel Genomic Sequence-Search on a Massively Parallel System." ACM International Conference on Computing Frontiers. May 7, 2007 - May 9, 2007. Ischia, Italy. ACM, May 2007.
Randles, A, Draeger, EW, and Michor, F. "Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations." Computing in Cardiology. September 7, 2014 - September 10, 2014. Cambridge, MA.
Randles, A, and Kaxiras, EK. "A Spatio-Temporal Coupling Method to Reduce the Time-to-Solution of Cardiovascular Simulations." International Parallel and Distributed Processing Symposium. May 19, 2014 - May 23, 2014. Full Text
Randles, A. "MIC-SVM: Designing A Highly Efficient Support Vector Machine for Advanced Modern Multi-Core and Many-Core Architectures." IEEE International Parallel and Distributed Processing Symposium. May 19, 2014 - May 23, 2014. Full Text
Randles, A, King, A, Budnik, T, McCarthy, P, Michaud, P, Mundy, M, Sexton, J, and Stewart, G. "Asynchronous task dispatch for high throughput computing for the eServer IBM Blue Gene Supercomputer." IEEE International Symposium on Parallel and Distributed Processing. April 14, 2008 - April 18, 2008. Miami, FL. Full Text