Harold Layton

  • Professor of Mathematics
External address: 221 Physics Bldg, Durham, NC 27708
Internal office address: Box 90320, Durham, NC 27708-0320
Phone: (919) 660-2809

Research Areas and Keywords

Biological Modeling
renal modeling

Professor Layton is modeling renal function at the level of the nephron (the functional unit of the kidney) and at the level of nephron populations. In particular, he is studying tubuloglomerular feedback (TGF), the urine concentrating mechanism, and the hemodynamics of the afferent arteriole. Dynamic models for TGF and the afferent arteriole involve small systems of semilinear hyperbolic partial differential equations (PDEs) with time-delays, and coupled ODES, which are solved numerically for cases of physiological interest, or which are linearized for qualitative analytical investigation. Dynamic models for the concentrating mechanism involve large systems of coupled hyperbolic PDEs that describe tubular convection and epithelial transport. Numerical solutions of these PDEs help to integrate and interpret quantities determined by physiologists in many separate experiments.

Education & Training
  • Ph.D., Duke University 1986

  • M.S., University of Kentucky at Lexington 1980

  • B.A., Asbury College 1979

Selected Grants

EMSW21-RTG: awarded by National Science Foundation (Co-Principal Investigator). 2010 to 2017

Modeling Solute Transport and Urine Concentrating Mechanism in the Rat Kidney awarded by National Institutes of Health (Collaborator). 2010 to 2016

Mathematical Models of Renal Dynamics awarded by National Institutes of Health (Principal Investigator). 2006 to 2010

A Conference on Applications of Analysis to Mathematical Biology awarded by National Science Foundation (Co-Principal Investigator). 2007 to 2008

Mathematical Models of Renal Dynamics awarded by National Institutes of Health (Principal Investigator). 1990 to 2005

Mathematical Sciences/GIG: Applications of Mathematics to Physiology awarded by National Science Foundation (Co-Principal Investigator). 1997 to 2001

(96-0846) Mathematical Modes of Renal Dynamics awarded by National Institutes of Health (Principal Investigator). 1990 to 2000

(97-0521) Applications of Mathematics to Physiology awarded by National Science Foundation (Co-Principal Investigator). 1997 to 1999

(97-0855) Mathematical Models of Renal Dynamics awarded by National Institutes of Health (Principal Investigator). 1990 to 1999

(94-1029) Mathematical Models of Renal Dynamics awarded by National Institutes of Health (Principal Investigator). 1990 to 1999

Pages

Sands, JM, Mount, DB, and Layton, HE. "The physiology of water homeostasis." Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance. November 1, 2013. 1-28. Full Text

Sands, JM, and Layton, HE. "Advances in understanding the urine-concentrating mechanism." Annual review of physiology 76 (January 2014): 387-409. (Review) Full Text

Nieves-González, A, Clausen, C, Layton, AT, Layton, HE, and Moore, LC. "Transport efficiency and workload distribution in a mathematical model of the thick ascending limb." Am J Physiol Renal Physiol 304.6 (March 15, 2013): F653-F664. Full Text

Sands, JM, and Layton, HE. "The Urine Concentrating Mechanism and Urea Transporters." Seldin and Geibisch's The Kidney 1 (2013): 1463-1510. Full Text

Dantzler, WH, Layton, AT, Layton, HE, and Pannabecker, TL. "Urine concentrating mechanism in the inner medulla: function of the thin limbs of Henle’s loops (Accepted)." Clinical Journal of the American Society of Nephrology. (August 2012). (Academic Article)

Layton, AT, Moore, LC, and Layton, HE. "Signal transduction in a compliant thick ascending limb." Am J Physiol Renal Physiol 302.9 (May 1, 2012): F1188-F1202. Full Text

Nieves-Gonzalez, A, Clausen, C, Layton, AT, Layton, HE, and Moore, LC. "Efficiency and workload distribution in a mathematical model of the thick ascending limb (Accepted)." American Journal of Physiology--Renal Physiology (2012). (Academic Article)

Nieves-Gonzalez, A, Clausen, C, Marcano, M, Layton, AT, Layton, HE, and Moore, LC. "Fluid dilution and efficiency of Na+ transport in a mathematical model of a thick ascending limb cell (Accepted)." American Journal of Physiology---Renal Physiology (2012). (Academic Article)

Layton, AT, and Layton, HE. "Countercurrent multiplication may not explain the axial osmolality gradient in the outer medulla of the rat kidney." Am J Physiol Renal Physiol 301.5 (November 2011): F1047-F1056. Full Text

Layton, AT, Bowen, M, Wen, A, and Layton, HE. "Feedback-mediated dynamics in a model of coupled nephrons with compliant thick ascending limbs." Math Biosci 230.2 (April 2011): 115-127. Full Text

Chen, J, Sgouralis, I, Moore, LC, Layton, HE, and Layton, AT. "A mathematical model of the myogenic response to systolic pressure in the afferent arteriole." Am J Physiol Renal Physiol 300.3 (March 2011): F669-F681. Full Text

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