Marc Daniel Ryser
- Assistant Professor in Population Health Sciences
- Instructor in the Department of Mathematics (Joint)
- Assistant Professor of Mathematics (Joint)
- Member of the Duke Cancer Institute
Research Areas and Keywords
PDE & Dynamical Systems
The Mathematics of Breast Cancer Overtreatment: Improving Treatment Choice through Effective Communication of Personalized Cancer Risk awarded by National Institutes of Health (Principal Investigator). 2018 to 2021
Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort awarded by Breast Cancer Research Foundation (Co Investigator). 2018 to 2019
Mathematical Analysis of Spatial Cancer Models awarded by National Science Foundation (Co-Principal Investigator). 2016 to 2019
The Mathematics of Breast Cancer Overtreatment: Improving Treatment Choice through Effective Communication of Personalized Cancer Risk awarded by National Institutes of Health (Principal Investigator). 2016 to 2018
Ryser, MD, Yu, M, Grady, W, Siegmund, K, and Shibata, D. "Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance." Scientific Reports 8.1 (November 23, 2018): 17292-null. Full Text
Ryser, MD, Gulati, R, Eisenberg, MC, Shen, Y, Hwang, ES, and Etzioni, RB. "Identification of the Fraction of Indolent Tumors and Associated Overdiagnosis in Breast Cancer Screening Trials." American Journal of Epidemiology (October 16, 2018). Full Text
Ryser, MD, Min, B-H, Siegmund, KD, and Shibata, D. "Spatial mutation patterns as markers of early colorectal tumor cell mobility." Proceedings of the National Academy of Sciences of the United States of America 115.22 (May 14, 2018): 5774-5779. Full Text
"Role of Preoperative Variables in Reducing the Rate of Occult Invasive Disease for Women Considering Active Surveillance for Ductal Carcinoma In Situ." JAMA surgery 153.3 (March 2018): 290-291. Full Text
Ryser, MD, Horton, JK, and Hwang, ES. "How Low Can We Go-and Should We? Risk Reduction for Minimal-Volume DCIS." Annals of surgical oncology 25.2 (February 2018): 354-355. Full Text
Shen, Y, Dong, W, Gulati, R, Ryser, MD, and Etzioni, R. "Estimating the frequency of indolent breast cancer in screening trials." Statistical Methods in Medical Research (January 2018): 962280217754232-null. Full Text
Grimm, LJ, Ryser, MD, Partridge, AH, Thompson, AM, Thomas, JS, Wesseling, J, and Hwang, ES. "Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials." Annals of Surgical Oncology 24.12 (November 2017): 3534-3540. Full Text
Cao, Y, Feng, Y, Ryser, MD, Zhu, K, Herschlag, G, Cao, C, Marusak, K, Zauscher, S, and You, L. "Programmable assembly of pressure sensors using pattern-forming bacteria." Nature Biotechnology 35.11 (November 2017): 1087-1093. Full Text
Ryser, MD, Rositch, A, and Gravitt, PE. "Modeling of US Human Papillomavirus (HPV) Seroprevalence by Age and Sexual Behavior Indicates an Increasing Trend of HPV Infection Following the Sexual Revolution." The Journal of Infectious Diseases 216.5 (September 2017): 604-611. Full Text
Ryser, MD, Gravitt, PE, and Myers, ER. "Mechanistic mathematical models: An underused platform for HPV research." Papillomavirus research (Amsterdam, Netherlands) 3 (June 2017): 46-49. (Review) Full Text
Ryser, MD, Weaver, DL, Marks, JR, Hyslop, T, and Hwang, ES. "Quantifying the natural history and overtreatment rate of ductal carcinoma in situ." February 2018.
Sarma, D, Worni, M, Greenup, RA, Ryser, MD, and Hwang, E. "The Impact of Socioeconomic and Geographic Factors on Ductal Carcinoma in situ Treatment." February 2015.
Worni, M, Ryser, MD, Guller, U, Greenup, RA, and Hwang, SE. "Trends in Tumor Characteristics among DCIS Patients: A Population-based Analysis of 130,229 Patients." February 2015.
"Impact of the spatial RANKL/OPG distribution on BMU branching." December 1, 2008.
Ryser, MD, Nigam, N, and Komarova, SV. "Spatio-temporal dynamics of a single bone remodeling." 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research. September 16, 2007 - September 19, 2007. Honolulu, HI.: AMER SOC BONE & MINERAL RES, September 1, 2007.
In cancer treatment, metastatic tumors receive equal treatment. Patients are given the same aggressive therapies when abnormal clusters of cells are discovered early, even if they may be harmless. In research studies co-led by Duke's Marc Ryser... read more »
Kevin Murgas (Biomedical Engineering, Class 2017), started working on this project during a Research Experience for Undergraduates (REU) program in mathematical biology in the summer of 2015. Together with his research mentor, Dr. Marc Ryser, they... read more »
A mathematical model from Duke University mathematicians suggests more can be done to protect people from the human papilloma virus. HPV is associated with cervical cancer in women, but can also cause various cancers in men. Duke mathematician... read more »
Active surveillance could be a viable alternative to surgery and radiation for select patients with ductal carcinoma in situ, or DCIS, according to a mathematical model developed by researchers at Duke University.... read more »
A new study adds to a growing conversation on the best way to treat women with stage 0 breast cancer http://time.com/4151717/dcis-breast-cancer-active-surveillance/ read more »