Marc Daniel Ryser

Marc Daniel Ryser
  • Assistant Professor in Population Health Sciences
  • Instructor in the Department of Mathematics (Joint)
  • Assistant Professor of Mathematics (Joint)
  • Member of the Duke Cancer Institute
External address: 299B Physics Bldg, 120 Science Drive, Durham, NC 27708
Internal office address: Box 90320, Durham, NC 27708
Phone: (919) 684-8294

Research Areas and Keywords

Biological Modeling
cancer biology, cancer epidemiology, early carcinogenesis, Human papillomavirus, cancer evolution
Computational Mathematics
cancer evolution
PDE & Dynamical Systems
bone biology, pattern formation
cancer biology, cancer epidemiology, early carcinogenesis, Human papillomavirus, cancer evolution

For a detailed description of past and current research projects, please visit

Areas of Expertise: Clinical Decision Sciences and Epidemiology

Education & Training
  • Ph.D., McGill University Faculty of Medicine 2011

  • Ph.D., McGill University (Canada) 2011

Selected Grants

Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort awarded by Breast Cancer Research Foundation (Co Investigator). 2018 to 2019

Mathematical Analysis of Spatial Cancer Models awarded by National Science Foundation (Co-Principal Investigator). 2016 to 2019

Ryser, MD, Gulati, R, Eisenberg, MC, Shen, Y, Hwang, ES, and Etzioni, RB. "Identification of the Fraction of Indolent Tumors and Associated Overdiagnosis in Breast Cancer Screening Trials." American Journal of Epidemiology 188.1 (January 2019): 197-205. Full Text

Ryser, MD, Yu, M, Grady, W, Siegmund, K, and Shibata, D. "Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance." Scientific Reports 8.1 (November 23, 2018): 17292-null. Full Text

Ryser, MD, Min, B-H, Siegmund, KD, and Shibata, D. "Spatial mutation patterns as markers of early colorectal tumor cell mobility." Proceedings of the National Academy of Sciences of the United States of America 115.22 (May 14, 2018): 5774-5779. Full Text

Ryser, MD, Horton, JK, and Hwang, ES. "How Low Can We Go-and Should We? Risk Reduction for Minimal-Volume DCIS." Annals of surgical oncology 25.2 (February 2018): 354-355. Full Text

Shen, Y, Dong, W, Gulati, R, Ryser, MD, and Etzioni, R. "Estimating the frequency of indolent breast cancer in screening trials." Statistical Methods in Medical Research (January 2018): 962280217754232-null. Full Text

Grimm, LJ, Ryser, MD, Partridge, AH, Thompson, AM, Thomas, JS, Wesseling, J, and Hwang, ES. "Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials." Annals of Surgical Oncology 24.12 (November 2017): 3534-3540. Full Text

Cao, Y, Feng, Y, Ryser, MD, Zhu, K, Herschlag, G, Cao, C, Marusak, K, Zauscher, S, and You, L. "Programmable assembly of pressure sensors using pattern-forming bacteria." Nature Biotechnology 35.11 (November 2017): 1087-1093. Full Text

Ryser, MD, Gravitt, PE, and Myers, ER. "Mechanistic mathematical models: An underused platform for HPV research." Papillomavirus research (Amsterdam, Netherlands) 3 (June 2017): 46-49. (Review) Full Text


Ryser, MD, Weaver, DL, Marks, JR, Hyslop, T, and Hwang, ES. "Quantifying the natural history and overtreatment rate of ductal carcinoma in situ." February 2018.

Sarma, D, Worni, M, Greenup, RA, Ryser, MD, and Hwang, E. "The Impact of Socioeconomic and Geographic Factors on Ductal Carcinoma in situ Treatment." February 2015.

Worni, M, Ryser, MD, Guller, U, Greenup, RA, and Hwang, SE. "Trends in Tumor Characteristics among DCIS Patients: A Population-based Analysis of 130,229 Patients." February 2015.

Ryser, MD, Nigam, N, and Komarova, SV. "Impact of the spatial RANKL/OPG distribution on BMU branching." December 1, 2008.

Ryser, MD, Nigam, N, and Komarova, SV. "Spatio-temporal dynamics of a single bone remodeling." 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research. September 16, 2007 - September 19, 2007. Honolulu, HI.: AMER SOC BONE & MINERAL RES, September 1, 2007.

  Shira at the Algebraic CombinatoriXX II workshop at BIRS last summer Shira Viel I received my PhD from North Carolina State University under the direction of Nathan Reading.  My thesis work was in algebraic and geometric combinatorics with a focus... read more »

Tumor ancestral trees are physically embedded within their tumors

In cancer treatment, metastatic tumors receive equal treatment.  Patients are given the same aggressive therapies when abnormal clusters of cells are discovered early, even if they may be harmless.  In research studies co-led by Duke's Marc Ryser... read more »

New Approach to Bone Remodeling

Kevin Murgas (Biomedical Engineering, Class 2017), started working on this project during a Research Experience for Undergraduates (REU) program in mathematical biology in the summer of 2015. Together with his research mentor, Dr. Marc Ryser, they... read more »

Study: Vaccinating Boys Against HPV Could Prevent Cancer In Men and Women

A mathematical model from Duke University mathematicians suggests more can be done to protect people from the human papilloma virus.    HPV is associated with cervical cancer in women, but can also cause various cancers in men.   Duke mathematician... read more »

Mathematical model suggests select DCIS patients could delay treatment

Active surveillance could be a viable alternative to surgery and radiation for select patients with ductal carcinoma in situ, or DCIS, according to a mathematical model developed by researchers at Duke University.... read more »