The Susceptible-Infectious-Recovered (SIR) equations and their extensions comprise a commonly utilized set of models for understanding and predicting the course of an epidemic. In practice, it is of substantial interest to estimate the model parameters based on noisy observations early in the… read more about this publication »
The Fleming-Viot particle system consists of N identical particles diffusing in a domain U⊂Rd. Whenever a particle hits the boundary ∂U, that particle jumps onto another particle in the interior. It is known that this system provides a particle representation for both the Quasi-Stationary… read more about this publication »
In this paper, we consider the dynamics of a 2D target-searching agent performing Brownian motion under the influence of fluid shear flow and chemical attraction. The analysis is motivated by numerous situations in biology where these effects are present, such as broadcast spawning of marine… read more about this publication »
Exponentially-localized Wannier functions (ELWFs) are an orthonormal basis of the Fermi projection of a material consisting of functions which decay exponentially fast away from their maxima. When the material is insulating and crystalline, conditions which guarantee existence of ELWFs in… read more about this publication »
The neurotransmitter dopamine (DA) is known to be influenced by the circadian timekeeping system in the mammalian brain. We have previously created a single-cell differential equations model to understand the mechanisms behind circadian rhythms of extracellular DA. In this paper, we investigate the… read more about this publication »
The 2-dimensional motion of a particle subject to Brownian motion and ambient shear flow transportation is considered. Numerical experiments are carried out to explore the relation between the shear strength, box size, and the particle’s expected first hitting time of a given target. The simulation… read more about this publication »
AbstractGiven a set P of n points and a constant k, we are interested in computing the persistent homology of the Čech filtration of P for the k-distance, and investigate the effectiveness of dimensionality reduction for this problem, answering an open question of Sheehy (The persistent homology of… read more about this publication »
Background: The application of heart rate variability is problematic in patients with atrial fibrillation (AF). This study aims to explore the associations between all-cause mortality and the median hourly ambulatory heart rate range (ÃHRR24hr) compared with other parameters obtained from the… read more about this publication »
The oscillations observed in many time series, particularly in biomedicine, exhibit morphological variations over time. These morphological variations are caused by intrinsic or extrinsic changes to the state of the generating system, henceforth referred to as dynamics. To model these time series (… read more about this publication »
Recent work of Sottoriva, Graham, and collaborators have led to the controversial claim that exponentially growing tumors have a site frequency spectrum that follows the 1/f law consistent with neutral evolution. This conclusion has been criticized based on data quality issues, statistical… read more about this publication »
In this work, we analyze the global convergence property of coordinate gradient descent with random choice of coordinates and stepsizes for non-convex optimization problems. Under generic assumptions, we prove that the algorithm iterate will almost surely escape strict saddle points of the… read more about this publication »
Numerical solutions to high-dimensional partial differential equations (PDEs) based on neural networks have seen exciting developments. This paper derives complexity estimates of the solutions of d-dimensional second-order elliptic PDEs in the Barron space, that is a set of functions admitting the… read more about this publication »
We propose a novel numerical method for high dimensional Hamilton-Jacobi-Bellman (HJB) type elliptic partial differential equations (PDEs). The HJB PDEs, reformulated as optimal control problems, are tackled by the actor-critic framework inspired by reinforcement learning, based on neural network… read more about this publication »
Abstract We study steady-state thin films on chemically heterogeneous substrates of finite size, subject to no-flux boundary conditions. Based on the structure of the bifurcation diagram, we classify the 1D steady-state solutions that exist on such substrates into six different… read more about this publication »
Flatly Foliated Relativity (FFR) is a new theory which conceptually lies between Special Relativity (SR) and General Relativity (GR), in which spacetime is foliated by flat Euclidean spaces. While GR is based on the idea that “matter curves spacetime”, FFR is based on the idea that “matter curves… read more about this publication »